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apalutamide will minimize the extent or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with prescription drugs which are CYP2C19 substrates can lead to decreased publicity to these medicines.enasidenib will enhance the degree or impact of